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FLASH GENE
Symbol CNST contributors: mct/npt - updated : 19-04-2010
HGNC name consortin, connexin sorting protein
HGNC id 26486
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putatively cytosolic, N-terminal segment which includes the connexin-interacting region and is highly disordered
  • short C-terminal tail well structured and likely to form a globular domain (Del Castillo 2010)
  • HOMOLOGY
    Homologene
    FAMILY
  • CNST family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text located at the trans-Golgi network (TGN), in tubulovesicular transport organelles, and at the plasma membrane (Del Castillo 2010)
    basic FUNCTION
  • role in the intracellular sorting of connexins, acts as a TGN receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (Del Castillo 2010)
  • first cargo receptor implicated in the traffic of integral membrane proteins (Del Castillo 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with the TGN clathrin adaptors GGA1 and GGA2 (Del Castillo 2010)
  • binding partner of connexins, the building blocks of gap junctions (Del Castillo 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS