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FLASH GENE
Symbol TMEM107 contributors: mct - updated : 24-08-2017
HGNC name transmembrane protein 107
HGNC id 28128
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton,intermed filament
basic FUNCTION
  • acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types
  • acts in the SHH pathway to determine digit number, but not identity, by regulating a subset of SHH target genes
  • is a novel factor required for ciliogenesis and Sonic hedgehog signaling
  • plays a key, conserved role in regulating ciliary protein composition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) JBTS29 , OFD16 , MKS13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS