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FLASH GENE
Symbol LBP contributors: - updated : 02-02-2004
HGNC name lipopolysaccharide binding protein
HGNC id 6517
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide,
  • a N terminal half with a LPS binding site,
  • four cysteine residues,
  • five glycosylation sites and
  • a conserved C terminal,with an octapeptide half required for anchoring lipoprotein particles
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY LBP/BPI/CETP family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular serum
    basic FUNCTION acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS
    endotoxin) from the cell wall of Gram- bacteria
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein contributing with CD14 to the activation of the mitogen-activated protein kinase p38 by lipopolysaccharides in neutrophils
    cell & other associating with chylomicrons and enabling them to rapidly bind bacterial toxin
    REGULATION
    activated by oestradiol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS