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FLASH GENE
Symbol SDE2 contributors: npt - updated : 02-12-2020
HGNC name SDE2 telomere maintenance homolog
HGNC id 26643
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ubiquitin-like (UBL) fold, which is cleaved at a diglycine motif via a PCNA-interacting peptide (PIP) box and deubiquitinating enzyme activity, and UBL domain plays an important role in regulating replication stress response
  • a DNA-binding SAP (SAF-A/B, Acinus and PIAS) domain (SAP domains are frequently found in proteins participating in the DNA repair process)
  • cleaved C-terminal SDE2 is required for antagonizing PCNA monoubiquitination triggered by ultraviolet (UV) damage
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • possible function in the DDR or in DNA repair
  • may be involved in a confined and specific DNA repair pathway, which is often the case with distinct DNA repair factors
  • is a new factor required for counteracting replication stress
  • PCNA-associated protein, playing a key role in maintaining active replication and counteracting replication stress by regulating the replication fork protection complex (FPC)
  • essential role for SDE2 in maintaining genomic integrity by stabilizing the FPC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SDE2 is a new genome surveillance factor regulated by PCNA interaction
  • SDE2 facilitates spliceosomal association of CACTIN/Cay1, with a functional link between SDE2 and CACTIN further supported by genetic interactions and pre-mRNA splicing assays
  • conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks
  • SDE2 directly interacts with the FPC component TIMELESS (TIM) and enhances its stability, thereby aiding TIM localization to replication forks and the coordination of replisome progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS