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FLASH GENE
Symbol DBX1 contributors: npt/KTN - updated : 17/10/2008
HGNC name developing brain homeobox 1
HGNC id 33185
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
  • HOMOLOGY
    interspecies homolog to cow DBX1 (88.6 pc)
    homolog to rattus Dbx1 (91 pc)
    homolog to murine Dbx1 (89.9 pc)
    Homologene
    FAMILY
  • H2.0 homeobox family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in patterning the central nervous system during embryogenesis
  • playing a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons
  • regulating the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS