basic FUNCTION
| transferring 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the nonreducing end of glucuronic acid (GlcUA) |
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. required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains |
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involved in the biosynthetic initiation and elongation of chondroitin sulfate and is the key enzyme responsible for the selective chain assembly of chondroitin/dermatan sulfate on the linkage region tetrasaccharide common to various proteoglycans containing chondroitin/dermatan sulfate or heparin/heparan sulfate chains |
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involved in glycosaminoglycan chain synthesis or modifications |
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required for normal chondroitin sulfate production in developing cartilage |