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FLASH GENE
Symbol CSGALNACT1 contributors: npt/shn - updated : 08/05/2011
HGNC name chondroitin sulfate N-acetylgalactosaminyltransferase 1
HGNC id 24290
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to Csgalnact1, Mus musculus
ortholog to Csgalnact1, Rattus norvegicus
ortholog to CSGALNACT1, Pan troglodytes
Homologene
FAMILY
  • chondroitin N-acetylgalactosaminyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • transferring 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the nonreducing end of glucuronic acid (GlcUA)
  • . required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains
  • involved in the biosynthetic initiation and elongation of chondroitin sulfate and is the key enzyme responsible for the selective chain assembly of chondroitin/dermatan sulfate on the linkage region tetrasaccharide common to various proteoglycans containing chondroitin/dermatan sulfate or heparin/heparan sulfate chains
  • involved in glycosaminoglycan chain synthesis or modifications
  • required for normal chondroitin sulfate production in developing cartilage
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • morphogenesis
  • extracellular matrix organization and biogenesis
  • PATHWAY
    metabolism
    signaling
  • heparin biosynthesis
  • chondroitin sulfate biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CSGalNAcT1 null mice display both reduced chondroitin sulfate and amount of short-chain chondroitin sulfate producion by half, smaller cartilage and abnormally aggregated and disarranged type-II collagen fibres in developing cartilage