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FLASH GENE
Symbol CEP97 contributors: mct - updated : 06-03-2018
HGNC name centrosomal protein 97kDa
HGNC id 26244
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six LRR (leucine-rich) repeats
  • one IQ domain
  • HOMOLOGY
    interspecies homolog to rattus Cep97 (79.3 pc)
    homolog to murine Cep97 (77.7 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • collaborating with CEP110, being involved in the suppression of a cilia assembly program
  • required for correct spindle formation and having a role in cytokinesis
  • required for recruitment of CEP110 to the centrosome
  • CEP97 and other genes involved in regulation of cilia assembly may accelerate our understanding of human ciliary diseases, including renal disease and retinal degeneration (
  • negative regulator of primary cilia formation
  • DYRK1A and CEP97 coordinate with PLK1 to promote Separase function to properly form multicilia in multiciliated cells (MCCs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CALM1 and CEP110
  • recruits CP110 to centrosomes (
  • KIF24 specifically interacts with CCP110 and CEP97, centrosomal proteins that play a role in regulating centriolar length and ciliogenesis
  • centriole elongation requires POC5 and is restricted by CCP110 and CEP97
  • TTBK2 has the potential to effectively phosphorylate CEP164 and CEP97 and inhibits the interaction between CEP164 and its binding partner DVL3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner
  • role for CEP152 in controlling centriole length in germline and somatic tissue, functioning via the centriole protein CEP97
  • interaction of CEP104 with CCP110, CEP97, end-binding (EB) protein, and tubulin
  • both endogenous CCP110 and CEP97 were able to bind to both SALL1FL and SALL1 mutant
  • CEP97 interacts with DYRK1A to modulate multiciliogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS