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FLASH GENE
Symbol CCDC136 contributors: mct - updated : 31-08-2022
HGNC name coiled-coil domain containing 136
HGNC id 22225
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two leucine-rich repeats (LRR)
  • two coiled-coil domains
  • four protein kinase C phosphorylation sites
  • HOMOLOGY
    interspecies homolog to rattus Ccdc136 (74.3 pc)
    homolog to murine Ccdc136 (72.8 pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass membrane protein
    basic FUNCTION
  • essential role of CCDC136-mediated acrosome formation in spermatogenesis and fertilization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    down-regulated in gastric cancer
    tumoral     --low  
    in gastric and colorectal cancer tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ccdc136(-/-) males were infertile, due to severe defect of disrupting acrosome formation