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FLASH GENE
Symbol CFAP65 contributors: mct - updated : 04-07-2017
HGNC name cilia and flagella associated protein 65
HGNC id 25325
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain
  • a MSP (major sperm protein) domain, that is present in sperm-specific proteins
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • roles of CFAP65 in spermatogenesis and flagellar development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential interaction and/or inter-regulation between CFAP65 and CFAP47 during spermiogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MIMAF4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rose-comb mutation in chickens can cause the partial loss of function of Cfap65 and lead to defective sperm motility in male homozygotes
  • Cfap65 is expressed specifically in sexually mature male mice but is absent in juvenile mice