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FLASH GENE
Symbol HDLBP contributors: mct/npt - updated : 24-09-2009
HGNC name high density lipoprotein binding protein
HGNC id 4857
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fourteen K homology (KH) motif
  • C-terminal domain binding to the histone methyltransferase SUV39H1 (Zhou 2008)
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to murine Hdlbp
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nuclear envelope,int
    text localize to heterochromatin (Wang 2005)
    basic FUNCTION
  • playing a role in cell sterol metabolism
  • may be functioning to protect cells from over-accumulation of cholesterol
  • RNA-binding protein previously implicated in heterochromatin formation and chromosome segregation (Zhou 2008)
  • plays a pivotal role in the endocrine regulation of both lipids and cholesterol (Chen 2003)
  • key regulator in proliferating cells (Felder 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in autism with deletion 2q37.3 (Feider 2009)
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS