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FLASH GENE
Symbol C1QTNF12 contributors: mct - updated : 20-02-2018
HGNC name C1q and TNF related 12
HGNC id 32308
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
  • FAM132 family, CTRP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • insulin-sensitizing adipokine, functioning as an anti-inflammatory adipokine that exerts beneficial actions on glucose metabolism
  • adipokine with anti-diabetic actions
  • directly activated the PI3K-AKT1 signaling pathway to suppress gluconeogenesis and promote glucose uptake, respectively
  • novel metabolic regulator linking adipose tissue to whole body glucose homeostasis through insulin-dependent and independent mechanisms
  • insulin-sensitizing adipokine that regulates glucose metabolism in liver and adipose tissue
  • is an insulin-sensitizing and anti-inflammatory adipokine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCSK3/furin was identified as the major proprotein convertase expressed by adipocytes that mediates the endogenous cleavage of C1QTNF12
  • is an adipocytokine that exerts beneficial actions on glucose metabolism
  • transcriptional regulator Krüppel-like factor (KLF15) is involved in the regulation of C1QTNF12 expression in adipocytes
  • hyperinsulinaemic induction in healthy lean human subjects significantly increased circulating levels of C1QTNF12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    new target molecule for the treatment of insulin resistance and diabetes
    ANIMAL & CELL MODELS
  • increasing adipolin expression ameliorates adipose tissue inflammation and promotes glucose clearance in obese mice
  • diet-induced obese (DIO) mice showed a significant reduction of plasma levels of full and total (full and cleaved) adipolin compared with control mice, resulting in an increase in the ratio of cleaved to full isoform
  • in mice, loss of a single Ctrp12 allele affects glucose and lipid metabolism in a sex-dependent manner