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FLASH GENE
Symbol CMPK2 contributors: mct - updated : 13-02-2008
HGNC name cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
HGNC id 27015
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal targeting signal
  • C-terminal domain containing all consensus motifs of a nucleoside monophosphate kinase
  • HOMOLOGY
    intraspecies homolog to high homology with TMPK
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity
  • first pyrimidine nucleoside monophosphate kinase that has been identified in mitochondria
  • may be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein able to phosphorylate dUMP, dCMP, CMP, and UMP with ATP as phosphate donor
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS