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FLASH GENE
Symbol MPRIP contributors: mct - updated : 23-08-2016
HGNC name myosin phosphatase Rho interacting protein
HGNC id 30321
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • myosin phosphatase complex family
  • RIP family proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • important regulatory component that controls the RhoA signaling pathway, thus regulating myosin light chain phosphatase activity and myosin phosphorylation in cells
  • playing an important role for regulating myosin light chain phosphorylation state and morphology invascular smooth muscle cells
  • originally identified as a binding partner of activated RHOA, is an actin-binding protein that interacts with PPP1R12C
  • is a novel target of MAPK8 signaling and a requirement for human cancer cell invasion
  • potential involvement of MPRIP in neuronal responses to acute ischemic insults
  • pivotal role of MPRIP expression in governing pericyte contractile phenotype and endothelial growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    RhoA signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targets myosin phosphatase to the contractile apparatus to dephosphorylate myosin light chains
  • interferes with RHOA-mediated transcription through its ability to disassemble the actomyosin cytoskeleton downstream of RHOA
  • MAPK8 target gene, is myosin phosphatase-Rho interacting protein (MPRIP)
  • NUAK2 is a second protein targeted by MPRIP to actin fibers (NUAK2-MPRIP association inhibits fiber disassembly and MYPT1-mediated MLC dephosphorylation)
  • SDCBP controls RAC1 through a specific association with the myosin phosphatase Rho interacting protein (MPRIP), which occurs in response to phosphorylation of SDCBP by SRC at Tyr4
  • interaction of PPP1R12A and myosin phosphatase-RHOA interacting protein (MRIP), causes co-localization of myosin phosphatase and RHOA to actomyosin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS