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FLASH GENE
Symbol SNF8 contributors: npt/ - updated : 29-10-2012
HGNC name SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
HGNC id 17028
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain involved in the formation of a heterotetrameric ESCRTII complex
  • HOMOLOGY
    Homologene
    FAMILY
  • SNF8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • detected on the limiting membrane of multivesicular endosomes
  • basic FUNCTION
  • required for efficient derepression of glucose-repressed genes
  • important role in ligand-induced EGFR and CXCR4 turnover, suggesting that termination of EGF signaling occurs prior to ESCRT-II engagement
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45
  • component of the ESCRT-II complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the N-terminal half of RILP
  • RILP interacts with SNF8 and VPS36 of ESCRT-II to mediate their membrane recruitment
  • MCM2 binds to SNF8 and MCM2 competes with ELL for binding to SNF8 thus potentially modulating the stability of Holo-ELL complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS