Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FAAP24 contributors: mct - updated : 01-06-2009
HGNC name chromosome 19 open reading frame 40
HGNC id 28467
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two HhH motifs necessary for interactions with FANCM (Ciccia 2007)
  • HOMOLOGY
    Homologene
    FAMILY
  • Fanconi anemia (FA) core complex family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for normal levels of FANCD2 monoubiquitylation following DNA damage
  • FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA
  • FANCM/FAAP24 complex is specifically required for the recruitment of replication protein A (RPA) to interstrand crosslinking (ICL)-stalled replication forks
  • FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • DNA-binding component of the FA core complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with the C-terminal domain of FANCM and may cooperate with FANCM to target the FA core complex to damaged DNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS