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FLASH GENE
Symbol ARHGEF40 contributors: npt/mct - updated : 22-01-2015
HGNC name Rho guanine nucleotide exchange factor (GEF) 40
HGNC id 25516
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal RhoGEF domain
  • a pleckstrin domain
  • three regions homologous to regions of the zebrafish Quattro protein, which is involved in morphogenetic movements mediated by the actin cytoskeleton
  • HOMOLOGY
    Homologene
    FAMILY
  • guanine exchange factor (GEF) family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    text
  • in both myoblasts and neuroblastoma cells, is concentrated around the nucleus
  • basic FUNCTION
  • guanine exchange factor activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interplay between ARHGEF40 and KRT8/KRT18 filaments plays a crucial role in tensile force-induced RHOA activation and consequent actin cytoskeletal reinforcement
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS