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FLASH GENE
Symbol SOCS7 contributors: mct - updated : 17-03-2020
HGNC name suppressor of cytokine signaling 7
HGNC id 29846
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal SH2 domain, was responsible for the binding to vinexin (likely one of the SH3 domains of vinexin interacts with a poly-proline region of SOCS7)
  • a central region containing several proline-rich regions
  • HOMOLOGY
    Homologene
    FAMILY
  • SOCS protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • potent regulator of glucose homeostasis and insulin signaling
  • inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation
  • shuttling protein that transports cytoplasmic proteins into the nucleus and contributes to cell cycle arrest
  • SOCS7 is involved in the regulation of thymic stromal lymphopoietin (TSLP) signaling in mast cells
  • SOCS7 controls Muller glia cell lamination, but it is not responsible for cone photoreceptor positioning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • vinexin (SORBS3) as a partner interacting with SOCS7 (interacts with vinexin and the actin cytoskeleton)
  • connection between septins, SOCS7, NCK1 signaling, and the DNA damage response
  • SOCS7 interact with PLCG1, one of the insulin-like growth factor-1 (IGF1) receptor downstream molecules
  • SOCS7, a Cullin 5-RING E3 ubiquitin ligase (CRL5 substrate adaptor protein, is also required for neocortical layering
  • by terminating RELN signaling, SOCS6 and SOCS7 may allow new cycles of RELN signaling to occur and these may be essential for cortical neuron migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease brains
    tumoral     --over  
    significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
    Susceptibility to obesity, disturbances in lipid metabolism and insulin resistance
    Variant & Polymorphism other associations between SOCS7 common variants and related haplotypes and obesity, Insulin resistance and lipid metabolism disorders
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Socs7 deficient mice develop islet hyperplasia in the setting of increased insulin sensitivity and normal glucose tolerance
  • lack of Socs7 is associated with severe skin disease in mice