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FLASH GENE
Symbol AGMO contributors: mct - updated : 30-05-2018
HGNC name alkylglycerol monooxygenase
HGNC id 33784
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fatty acid hydroxylase motif, motif found in enzymes which contain a di-iron center and which carry out hydroxylations of lipids at aliphatic carbon atoms like alkylglycerol monooxygenase
  • HOMOLOGY
    Homologene
    FAMILY
  • tetrahydrobiopterin-dependent enzymes family
  • TMEM195 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having a catalytic activity
  • regulatory enzyme in lipogenesis, catalyzing the rate-limiting step in the overall de novo synthesis of mono-unsaturated FA, mainly oleate and palmitoleate from stearoyl- and palmitoyl-CoA, respectively
  • cleave the O-alkyl bond of ether lipids which are essential components of brain membranes, protect the eye from cataract, interfere or mediate signaling processes, and are required for spermatogenesis
  • only enzyme known to degrade the ether bond of lipids without known restrictions to their subclass, and may contribute to regulation of the concentration of these lipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to autism spectrum disorder
  • to intracranial aneurysms
  • to decreased glucose-stimulated insulin response
  • Variant & Polymorphism SNP , other
  • de novo copy number variant in autism spectrum disorder
  • rs4628172 and rs7781293 increasing the risk of intracranial aneurysms
  • variants at the DGKB/AGMO, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS