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FLASH GENE
Symbol RPAIN contributors: mct - updated : 05-05-2020
HGNC name RPA interacting protein
HGNC id 28641
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal arginine-rich basic region
  • a RIP-type zinc finger
  • an acidic region and two C-terminal Zn finger-like structures
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • mediating the import of RPA complex into the nucleus, possibly via some interaction with importin beta
  • might be involved in the basic cell function, and plays a role in the alternative nuclear ingress
  • is involved in cell proliferation through regulation of RPA1 transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the RPA1 subunit of RPA complex
  • is the nuclear transporter of RPA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may contribute to the development of preeclampsia through regulating trophoblast invasion and apoptosis via C1Q
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential diagnostic target for preeclampsia
  • Therapy target
    SystemTypeDisorderPubmed
    reproductionpregnancy 
    potential therapeutic target for preeclampsia
    ANIMAL & CELL MODELS