protein
| IRF2/NFKB interaction may play a role in the contexts of tumorigenesis |
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nucleolin is recruited to acetylated IRF2, thereby contributing to gene regulation crucial for the control of cell growth |
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interacting with MDM2 (Pettersson 2009) |
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HPV-16 E7 expression downregulates the IRF2 promoter, thus linking IRF2 levels to viral transforming gene expression through a negative feedback mechanism |
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multi-faceted role of IRF2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR-dependent manner and antibody production via up-regulation of PRDM1 |
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IRF1 and IRF2 could bind to IFP35 promoter and upregulate endogenous IFP35 protein level |
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IRF2 binds INPP4B promoter and promotes INPP4B expression in Acute myeloid leukemia (AML) cells |
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IRF1 and IRF2 bind to the TRIM14 promoter and activate transcription of TRIM14 |
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IRF2, is required for pyroptosis following cytosolic LPS delivery and functions by directly regulating CASP4 levels in human monocytes |
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IRF2 was found to be a transcriptional activator of CASP4, and in its absence, induction of IRF1 could substitute to maintain CASP4 expression |