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FLASH GENE
Symbol IRF2 contributors: mct/npt - updated : 06-04-2020
HGNC name interferon regulatory factor 2
HGNC id 6117
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ISRE (interferon stimulated response element)
  • a DNA binding domain at the N terminus (with tandem repeats)
  • a helix-hairpin-strand motif at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • IRF family
  • CATEGORY regulatory , transcription factor , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • repressor of IRF1, functioning as a transcriptional activator of histone H4
  • regulates NFKB activity via the modulation of NFKB subcellular localization
  • is acetylated in a cell growth-dependent manner, which enables it to contribute to the transcription of cell growth-regulated promoters
  • involved in the initiation and progression of tumors
  • IRF2 regulates exocytosis in pancreatic acinar cells, and defects in this process might be involved in the early phases of acute pancreatitis
  • IRF1 and IRF2 may regulate the progression of pancreatic cancer by functioning as an antioncoprotein and oncoprotein, respectively
  • IRF2, an ISG and a negative regulator of IFN signaling, influences alphavirus neuroinvasion and pathogenesis
  • is an important regulator of the proinflammatory response in macrophages by controlling HIF1A-dependent glycolytic gene expression and glycolysis
  • IRF2 regulates pro-inflammatory response in macrophages and could also impair epidermal function critically required to maintain the essential skin barrier
  • is a master regulator of human keratinocyte stem cell fate
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to interferon stimulated response element (ISRE)
    RNA
    small molecule
    protein
  • IRF2/NFKB interaction may play a role in the contexts of tumorigenesis
  • nucleolin is recruited to acetylated IRF2, thereby contributing to gene regulation crucial for the control of cell growth
  • interacting with MDM2 (Pettersson 2009)
  • HPV-16 E7 expression downregulates the IRF2 promoter, thus linking IRF2 levels to viral transforming gene expression through a negative feedback mechanism
  • multi-faceted role of IRF2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR-dependent manner and antibody production via up-regulation of PRDM1
  • IRF1 and IRF2 could bind to IFP35 promoter and upregulate endogenous IFP35 protein level
  • IRF2 binds INPP4B promoter and promotes INPP4B expression in Acute myeloid leukemia (AML) cells
  • IRF1 and IRF2 bind to the TRIM14 promoter and activate transcription of TRIM14
  • IRF2, is required for pyroptosis following cytosolic LPS delivery and functions by directly regulating CASP4 levels in human monocytes
  • IRF2 was found to be a transcriptional activator of CASP4, and in its absence, induction of IRF1 could substitute to maintain CASP4 expression
  • cell & other
    REGULATION
    induced by induced in IFN-stimulated cells
    Other sumoylation of IRF2 regulates likely its transcriptional activities
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    induces a rapid, dramatic, and sustained enhancement of stem cell function in human keratinocytes
    constitutional       loss of function
    results in dampened inflammasome responses upon infection with Gram-negative bacteria
    Susceptibility
  • to atopic dermatitis in japanese patients
  • to psoriasis (PSORS13)
  • Variant & Polymorphism SNP 921G/A SNP in exon 9 increasing the risk of psoriasis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    therapeutic target to treat inflammatory disorders associated with dysregulations of macrophage activations
    cancerhemopathy 
    IRF2 may be a potential target for Acute myeloid leukemia (AML) treatment
    ANIMAL & CELL MODELS