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FLASH GENE
Symbol YIPF5 contributors: mct - updated : 08-07-2020
HGNC name Yip1 domain family, member 5
HGNC id 24877
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a long soluble N-terminal region, which is orientated towards the cytosol, followed by
  • 5 closely stacked transmembrane domains,
  • a C terminus, orientated towards the lumen of the Golgi
  • HOMOLOGY
    interspecies homolog to yeast Yip1p
    Homologene
    FAMILY small Rab GTPase interacting factor protein family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text
  • highest level of expression was found in coronary smooth muscle cells
  • primarily localise to the Golgi complex, and part of cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5)
  • basic FUNCTION
  • may play an important role in inflammation
  • role for this family of proteins in regulating membrane dynamics in the endomembrane system
  • YIPF5 is essential for DNA virus- or intracellular DNA-triggered production of type I IFNs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with YIF1A and determines its localization to the Golgi apparatus
  • ability of YIPF5 to bind its established binding partners may be uncoupled from its ability to control ER whorl formation
  • YIPF5 is a positive regulator of STING1 trafficking
  • cell & other
    REGULATION
    induced by by transforming growth factor beta1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS