basic FUNCTION
| required with BRCA2 for homologous recombination repair and necessary for the correct association of BRCA2 with chromatin |
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integral component of the BRCA complex important for recombinational DNA repair |
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molecular scaffold in the formation of BRCA1-PALB2-BRCA2 complex |
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not only regulates the efficiency of homologous recombination but also dictates the specific homologous recombination pathway in which it participates |
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central core of a BRCA1 |
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PALB2 |
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BRCA2 complex essential for homologous recombination |
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can work in concert with a BRCA2 construct to further promote D-loop formation |
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important regulator of homologous recombination |
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crucial mediator of homologous recombination in cells, thus providing a plausible mechanism for the development of cancer |
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multifaceted role of PALB2 in chromosome damage repair |
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stabilizes BRCA2 by promoting its chromatin association |
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stimulates the ability of RAD51 to make D loops |
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BRCA2 and PALB2 are main regulators of G2 checkpoint maintenance following DNA-damage |
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regulator of cellular redox homeostasis and provide a new link between oxidative stress and the development of cancer and Fanconi anemia |
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essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks |
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required for DNA repair by homologous recombination (HR) |
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may link HR to a key ubiquitin-related signaling pathway that responds to DSBs |