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FLASH GENE
Symbol PID1 contributors: mct - updated : 22-10-2011
HGNC name phosphotyrosine interaction domain containing 1
HGNC id 26084
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
phosphotyrosine-binding domain (PTB)
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • increasing proliferation of preadipocytes
  • regulates the functions of IR-1 and AKT1, decreases SLC2A4 translocation and reduces glucose uptake in response to insulin
  • may be an important mediator in the development of obesity-related insulin resistance
  • involved in obesity-associated insulin resistance
  • regulatory function in adipocyte insulin sensitivity
  • potential role in glucose homeostasis and the development of insulin resistance in obesity
  • PID1 is a potent intracellular inhibitor of insulin signaling pathway during obesity
  • PID1 may likely have a tumor inhibitory function in these pediatric and adult brain tumors
  • PID1 serves as an insulin-regulated retention adaptor protein controlling translocation of LRP1 in conjunction with SLC2A4 to the plasma membrane of adipocytes
  • PID1 in adipose tissue increases lipolysis by altering the antilipolytic action of insulin
  • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PID1 serves as a cytosolic adaptor protein of the LDL receptor-related protein 1 (LRP1)
  • by acting as an insulin-dependent retention adaptor, PID1 serves as a regulator of LRP1 function controlling the disposal of postprandial lipoproteins
  • cell & other adipocytes and preadipocytes cells
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway
    constitutional     --over  
    in the adipose tissue of obese subjects
    tumoral     --low  
    in glioblastomas (GBM)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may represent a new therapeutic target to ameliorate adipocyte lipolysis and hence improve insulin sensitivity
    ANIMAL & CELL MODELS