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FLASH GENE
Symbol PMS1 contributors: np/ - updated : 19-05-2006
HGNC name PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
HGNC id 9121
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region of homology with other MutS or MutL homologs, comprising a region of 150 aminoacids
  • a putative helix-turn-helix domain
  • an adenine nucleotide and magnesium binding sites
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast mutator gene (bacterial mutL)
    Homologene
    FAMILY
  • DNA mismatch repair mutL/hexB family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • correctin of base-base mismatches and insertion-deletion loops resulting from DNA replication and recombination events
  • possessing an intrinsic low-level ATPase actvity
  • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, repair, mismatch repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with MLH1 and MLH2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLH1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HNPCC3
    related resource Internationa lGroup on Hereditary Non-Polyposis Colorectal Cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS