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FLASH GENE
Symbol KLHDC10 contributors: mct - updated : 21-10-2014
HGNC name kelch domain containing 10
HGNC id 22194
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Slim
ortholog to murine 2410127E18Rik
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • KLHDC10 is likely a cell-type specific regulator of necroptosis that ultimately contributes to the development of TNF-induced Systemic inflammatory response syndrome (SIRS)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KLHDC10 bound to the phosphatase domain of PPP5C and suppressed its phosphatase activity
  • is an activator of MAP3K5, contributing to oxidative stress-induced cell death through the suppression of PPP5C
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • KLHDC10-deficient mice show a reduction in the inflammatory response, but not in early systemic necroptosis