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FLASH GENE
Symbol PLPPR5 contributors: mct/npt - updated : 07-09-2020
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a well-conserved PAP2 motif
  • HOMOLOGY
    interspecies homolog to to PRG3
    Homologene
    FAMILY
  • plasticity-related gene family, PLPPR family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text in neurons, distributed in the plasma membrane and induces filopodia as well as axon elongation and growthb (Broggini 2010)
    basic FUNCTION
  • induces filopodia growth independently of CDC42 (Broggini 2010)
  • impedes brain injury-associated growth inhibitory signals upstream of the RhoA-Rho kinase pathway (Broggini 2010)
  • promotes spine formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLPPR5 interacts with phosphorylated phosphatidylinositols, phospholipids involved in dendritic spine formation by different lipid-protein assays
  • new functional cooperation between PLPPR family members and discovered for the first time that PLPPRs likely exert their function through forming complex with its family members
  • cell & other
    REGULATION
    Other regulated during brain and spinal cord development and is exclusively allocated within the nervous system (Broggini 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS