Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NIBAN2 contributors: mct - updated : 13-04-2021
HGNC name niban apoptosis regulator 2
HGNC id 25282
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PH or pleckstrin homology domain found near the N-terminus of the polypeptide (AAs 69192)
  • near the C terminus is a region rich in proline phosphorylated at six serine residues (AAs 628730))
  • HOMOLOGY
    interspecies ortholog to murine 9130404D14Rik
    Homologene
    FAMILY
  • Niban family, FAM129 protein family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • can be localized in the cytosol or associated with the cell junctions
  • localized in the plasma cell membrane during mitosis
  • basic FUNCTION
  • plays a critical role in cancer cell invasion
  • implicated in cell invasion in human melanoma cells in a process controlled by the Erk1/2 signaling cascade
  • one crucial facet of the mechanism by which FAM129B promotes cancer cell invasion is likely to be the suppression of apoptosis
  • expression of NIBAN2 in epidermal keratinocytes accompanied by alteration of wound healing-related gene expression is likely necessary for regulation of cell motility and thereby, contributes to the appropriate wound healing process
  • role for FAM129B in linking WNT/CTNNB1 signaling to apoptosis in melanoma
  • is involved in key signaling pathways regulating cell survival, proliferation and apoptosis and found upregulated in many types of cancer promoting invasion
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • normal component of the adherens junction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of the MAP kinase (Erk1/2) signaling cascade in human melanoma cells
  • NIBAN2 phosphorylation increased the interaction between NIBAN2 and RAS, resulting in reduced binding of RASA1 to RAS
  • NIBAN2 induces NFE2L2 by competing for Kelch-like ECH-associated protein 1 (KEAP1) binding (the negative regulator of NFE2L2) via an ETGE motif
  • phosphorylation of NIBAN2 plays a significant role in driving the metastatic potential of BRAF V600E melanoma via upregulation of the NFE2L2 signaling pathway
  • cell & other
    REGULATION
    Other rapid cleavage of FAM129B and cadherin that occurred during apoptosis may be a mechanism that ensures that the antiapoptotic function
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    is a potential therapeutic target
    ANIMAL & CELL MODELS