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FLASH GENE
Symbol BUD13 contributors: mct - updated : 08-04-2022
HGNC name BUD13 homolog (S. cerevisiae)
HGNC id 28199
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Bud13 (80.6 pc)
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • BUD13 showed significant interaction effects with calcium intake tertiles or sufficiency in both men and women
  • by acting as an antagonist to Intron retention (IR), BUD13 facilitates the expression of genes at which IR occurs
  • BUD13 is an RNA-binding protein that acts at the IR to increase the amount of successful splicing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Specific language impairment (SLI)
  • to metabolic syndrome
  • Variant & Polymorphism other
  • Variants in BUD13 associated with SLI
  • BUD13 rs11216129, BUD13 rs623908 are associated with metabolic syndrome
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS