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FLASH GENE
Symbol WDR45 contributors: mct - updated : 22-12-2018
HGNC name WD repeat domain 45
HGNC id 28912
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three WD repeats
  • a conserved motif for interaction with phospholipids
  • secondary structure seven-bladed beta-propeller structure
    HOMOLOGY
    Homologene
    FAMILY the WIPI subfamily of WD40 repeat proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions
  • beta-propeller scaffold protein with a putative role in autophagy
  • beta-propeller protein postulated to play a role in autophagy
  • plays a key role in autophagy
  • WIPI proteins function as essential phosphatidylinositol 3-phosphate (PtdIns3P) effectors at the nascent autophagosome
  • novel function of WDR45/45B in autophagosome-lysosome fusion
  • WDR45 and WDR45B are critical for autophagosome-lysosome fusion in neural cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AMPK-related kinases NUAK2 and BRSK2 regulate autophagy through WDR45
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NBIA5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS