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FLASH GENE
Symbol WDR45B contributors: mct - updated : 10-10-2022
HGNC name WD repeat domain 45B
HGNC id 25072
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two WD40 repeats
  • two sites embedded in blades 5 and 6 for recognizing phosphoinositides, resembling that in Hsv2
  • secondary structure seven-bladed beta-propeller structure
    HOMOLOGY
    Homologene
    FAMILY WIPI subfamily of WD40 repeat proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions
  • WIPI proteins function as essential phosphatidylinositol 3-phosphate (PtdIns3P) effectors at the nascent autophagosome
  • WDR45B is likely critical for neural homeostasis
  • novel function of WDR45/45B in autophagosome-lysosome fusion
  • WDR45 and WDR45B are critical for autophagosome-lysosome fusion in neural cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WDR45B associates with AMPK-activated TSC complex at lysosomes, regulating MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDSBAS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficient in Wdr45b exhibit motor deficits and learning and memory defects; Histological analysis reveals that Wdr45b knockout (KO) mice exhibit a large number of swollen axons and show cerebellar atrophy