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FLASH GENE
Symbol WIPI1 contributors: SGE/npt - updated : 06-04-2010
HGNC name WD repeat domain, phosphoinositide interacting 1
HGNC id 25471
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • LXXLL signature motifs for nuclear receptor interactions
  • three WD repeats
  • HOMOLOGY
    interspecies homolog to murine Wipi1 (94.4pc)
    homolog to rattus Wipi1 (94.3pc)
    Homologene
    FAMILY
  • WIPI subfamily of WD40 repeat proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text trans-elements of the Golgi and peripheral endosomes, clathrin-coated vesicles
    basic FUNCTION
  • may play a role in autophagy, and autophagic capacity may be compromised in cancers (Proikas-Cezanne 2007)
  • may regulate the trafficking of proteins involved in the
  • mannose-6-phosphate receptor (MPR) recycling pathway
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory component of the endosomal and mannose-6-phosphate receptor pathway (Jeffries 2004)
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • binding phosphatidyl-inositol-3-phosphate, PtdIns3,5P2
  • protein
  • probably interacts with androgen (AR) and the estrogen receptor (ER)
  • interacting with RAR, RXR (Proikas-Cezanne 2004)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    upregualted in various tumor tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS