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FLASH GENE
Symbol LGR6 contributors: mct - updated : 18-12-2023
HGNC name leucine-rich repeat-containing G protein-coupled receptor 6
HGNC id 19719
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal extracellular domain (ECD) composed of 17 leucine-rich repeats
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Lgr6 (90.7 pc)
    homolog to murine Lgr6 (90.2 pc)
    Homologene
    FAMILY
  • G protein-coupled 7-transmembrane protein superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • acting as a glycoprotein hormone receptor
  • potentially marks the most primitive epidermal stem cell
  • nerve endings/Schwann cells control LGR6 expression in skin, implying that they play a role in regulation of skin epithelial cells
  • potential direct role for LGR6-expressing cells during digit tip regeneration
  • LGR6 epidermal stem cells are primed for injury response and interact with nerves to regulate their fate (
  • oncogenic roles of LGR6 overexpression induced by aberrant WNT/CTNNB1 signaling in lung cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • each of the four R-spondins, secreted Wnt pathway agonists, can bind to LGR4, LGR5 and LGR6
  • LGR6 had a close interaction with RSPO1, RSPO2, RSPO3, and RSPO4
  • LGR6 expression appeared to be downregulated by the ubiquitin-proteasome system involving ZNRF3
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage probably by ATM or ATR
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma (ESCC), significantly higher than that in normal tissues
    tumoral       gain of function
    in ovarian cancer, which positively correlated with poor chemotherapeutic response and progression survival in ovarian cancer patients
    tumoral     --over  
    in small cell lung cancer (SCLC) and NSCLC cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    LGR6 as a potential therapeutic target in ovarian cancer
    ANIMAL & CELL MODELS
  • Lgr6-deficient mice, which have both a nail and bone regeneration defect