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FLASH GENE
Symbol LETMD1 contributors: mct - updated : 19-03-2007
HGNC name LETM1 domain containing 1
HGNC id 24241
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Letmd1 (80.00 pc)
Homologene
FAMILY
CATEGORY regulatory , protooncogene
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • may be a negative regulator of the p53 tumor suppressor
  • playing a role in developpement of human breast cancer
  • acting as a negative regulator of TP53 and contributes to tumorigenesis of various organs including the colon
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with REEP5
    cell & other
    REGULATION
    induced by the PI3K/Akt signaling pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS