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FLASH GENE
Symbol GPR174 contributors: mct - updated : 13-09-2023
HGNC name G protein-coupled receptor 174
HGNC id 30245
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Gpr174 (88.3pc)
Homologene
FAMILY G-protein coupled receptor 1 family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may have a purinergic nucleotide receptor activity
  • negatively regulates immune-cell proliferation by increasing intracellular cAMP
  • may play important roles in the central nervous system as a lysophosphatidylserine (LysoPS) receptor
  • is involved in the immune response
  • GPR174 plays likely an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions
  • has a role in restraining T cell responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCL21 is a GPR174 ligand (involved in sex-dependent control of B-cell positioning and participation in germinal centres)
  • GPR174 can signal via GNAS to modulate B cell gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Graves disease
    Variant & Polymorphism SNP
  • rs3827440 associated to Graves disease
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    may be a promising target for therapeutic agents to regulate inflammatory disorders
    immunologyautoimmune 
    GPR174 antagonists might have therapeutic potential for promoting immune regulation in the context of autoimmune disease
    ANIMAL & CELL MODELS