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FLASH GENE
Symbol LPCAT2 contributors: mct - updated : 09-03-2017
HGNC name lysophosphatidylcholine acyltransferase 2
HGNC id 26032
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • phospholipid/glycerol acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • LPCAT1 and LPCAT2 can localize to the lipid droplets (LDs)surface
  • basic FUNCTION
  • acyltransferase activity
  • LPCAT1 and LPCAT2 have, in addition to their known function in specialized cells, a ubiquitous role in lipid droplets (LDs)-associated lipid metabolism
  • under inflammatory conditions, LPCAT2, but not LPCAT1, is activated and upregulated to produce platelet-activating factor (PAF)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • platelet-activating factor (PAF), a potent proinflammatory lipid mediator, is synthesized rapidly in response to extracellular stimuli by the activation LPCAT2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast, cervical, and colorectal cancer tissues, indicating its adjuvant role in the progression of these cancers
    constitutional     --over  
    in the ipsilateral spinal cord after injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS