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FLASH GENE
Symbol SYNPO2L contributors: npt - updated : 26-05-2006
HGNC name synaptopodin 2-like
HGNC id 23532
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • rich in proline and containing multiple PXXP motifs that could function as potential peptide ligand motifs for SH3 domain containing proteins
  • one PPXY motif
  • HOMOLOGY
    intraspecies homolog to synaptopodin
    Homologene
    FAMILY
  • synaptopodin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localized in dense bodies and in Z-lines of striated muscle
    basic FUNCTION
  • increases the rate of actin polymerization by accelerating the nucleation phase and exhibits a high potency to bundle actin filaments
  • playing a role in organizing cellular actin
  • may be stabilizing the formation of actin nuclei
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the cytoskeleton
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with calmodulin in a Ca2+-dependent manner
  • actin binding protein
  • multiple binding partners including myosin, calmodulin and alpha-actinin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS