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FLASH GENE
Symbol HECTD2 contributors: mct/npt - updated : 17-08-2009
HGNC name HECT domain containing 2
HGNC id 26736
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • E3 ubiquitin ligase, having an ubiquitin-protein ligase activity
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other heme binding
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to human prion diseases
  • Variant & Polymorphism SNP SNP, rs12249854(A/T), located in a HECTD2 intron, influencing susceptibility to human prion diseases (Tank 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS