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FLASH GENE
Symbol MXD1 contributors: mct/npt/pgu - updated : 09-09-2009
HGNC name MAX dimerization protein 1
HGNC id 6761
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic helix-loop-helix (bHLH) motif
  • a nuclear localization signal
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Mxd1 (89.6 pc)
    homolog to murine Mxd1 (89 pc)
    Homologene
    FAMILY
  • subfamily of MAX-interacting proteins
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor
  • antagonizing MYC transcriptional activity through interaction with the N-COR/SIN3/HDAC corepressor complex (by the recruitment of opposing chromatin remodeling activities compared to Myc)
  • inhibiting apoptosis via downregulation of PTEN expression
  • interacts with NEK2 at the kinetochore and possibly functions as a novel integrator of spindle checkpoint signaling
  • key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text multicellular organismal development
    PATHWAY
    metabolism
    signaling
    a component
  • forming a sequence-specific DNA-binding complex with MAX
  • part of the MYC-MAX-MXD1 network
  • INTERACTION
    DNA binding the enhancer box (E box) hexanucleotide (5-prime-CACGTG-3-prime) when heterodimerized with MAX
    RNA
    small molecule
    protein
  • Max heterodimeric partner
  • TERT telomerase reverse transcriptase
  • cell & other
    REGULATION
    induced by CSF3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS