Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ADAT2 contributors: mct - updated : 12-09-2023
HGNC name adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae)
HGNC id 21172
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a AAA type ATPase domain
  • a bromodomain
  • HOMOLOGY
    interspecies homolog to S.Cerevisiae Tad2
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminase family
  • ADAT2 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acts potentially on upstream and basic cellular processes to enhance oncogenesis in a variety of unrelated cell types
  • controls chromatin dynamics, genome transcriptional activities and apoptotic cell response
  • its overexpression in somatic cells, by acting on basic properties of chromatin, may contribute to malignant transformation
  • key role for the inactive ADAT3 deaminase domain in proper assembly with ADAT2, demonstrating that ADAT2/3 nuclear import is required for maintaining proper levels of the wobble inosine modification in tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric enzyme ADAT (hetADAT), is composed of two subunits: ADAT2 and ADAT3 (ADAT2 is considered the catalytic subunit while ADAT3 might be playing a role in tRNA substrate recognition)
  • heterodimer ADAT3 / ADAT2 is involved in the adenosine-to-inosine conversion in tRNA
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ADAT2, is proposed as a predictive biomarker of efficacy of treatments recently recommended to patients with BRCA1 deficiency
  • Therapy target
    ANIMAL & CELL MODELS