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FLASH GENE
Symbol DDX59 contributors: mct - updated : 17-10-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
HGNC id 25360
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a HIT-type zinc finger
  • a Q motif
  • an helicase ATP-binding domain
  • a DEAD box
  • an helicase C-terminal domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Ddx59 (84 pc)
    homolog to murine Ddx59 (83.5 pc)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX59 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • dynamically to the nucleus and the cytoplasm
  • basic FUNCTION
  • playing an helicase role
  • controlling ATP binding and hydrolysis through its Q motif
  • play a critical role in all aspects of RNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule metal binding, nucleotide,
  • Zn2+
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OFD5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS