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FLASH GENE
Symbol TKFC contributors: mct - updated : 05-03-2020
HGNC name triokinase and FMN cyclase
HGNC id 24552
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DAK1 (dihydroxyacetone kinase subunit 1) domain
  • a DAK2 (dihydroxyacetone kinase subunit 2) domain
  • an FMN lyase domain
  • HOMOLOGY
    Homologene
    FAMILY dihydroxyacetone kinase (DAK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the phosphorylation of dihydroxyacetone
  • physiological suppressor of IFIH1 and specifically inhibits IFIH1- but not DDX58-mediated innate antiviral signaling
  • phosphorylates exogenous dihydroxyacetone and fructose-derived glyceraldehyde, is neither molecularly identified nor firmly associated to an encoding gene
  • catalyzes the adenosine triphosphate (ATP)-dependent phosphorylation of D-glyceraldehyde and dihydroxyacetone (DHA), and the cyclizing splitting of flavin adenine dinucleotide (FAD)
  • bifunctional enzyme involved in fructose metabolism through its glyceraldehyde kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein specific IFIH1-interacting protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TKFCD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS