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FLASH GENE
Symbol CRELD2 contributors: mct/pgu - updated : 16-10-2013
HGNC name cysteine-rich with EGF-like domains 2
HGNC id 28150
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tryptophan-glutamic acid rich domain (WE)
  • EGF binding domain
  • Ca binding domain
  • EGF/Ca binding domain
  • furin cysteine-rich domain
  • HOMOLOGY
    interspecies homolog to rattus Creld2 (77,08 pc)
    homolog to murine Creld2 (75,71 pc)
    Homologene
    FAMILY
  • CRELD family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text localized in ER
    basic FUNCTION
  • secreted CRELD2 isoforms may modulate CRELD1 function by competitive binding
  • may acts as an extracellular competitor of CRELD1
  • CRELD2 may regulates CRELD1 function
  • may play a role in AVSD
  • could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases
  • MANF and CRELD2 are genotype-specific ER stress response proteins with substrate specificities
  • exogenous CRELD2 promotes GDF2-induced ectopic bone formation and matrix mineralization, whereas silencing CRELD2 expression diminishes GDF2-induced bone formation and matrix mineralization
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRELD2 may be directly regulated by GDF2
  • CRELD2 and MANF, are oppositely regulated by the overexpression of 78&
  • 8201;kDa glucose-regulated protein (HSPA5)
    cell & other
    REGULATION
    induced by ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS