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FLASH GENE
Symbol CD47 contributors: mct/npt - updated : 13-06-2012
HGNC name CD47 molecule
HGNC id 1682
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one immunoglobulin-like V-type domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to RH related
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY antigen , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text colocalizing with the Rho protein complex
    basic FUNCTION
  • integrin-associated signal transducer, marker of self on red blood cells
  • may play a role in membrane transport and/or signal transduction
  • may be involved in membrane permeability changes induced following virus infection
  • implicated in functions as diverse as neutrophil migration, promotion of neurite and filopodium formation by CD47, and T cell costimulation
  • its signaling can negatively affect the viability and function of cerebral endothelial cells
  • T cell-negative regulator of type 1 responses that may limit unwanted collateral damage to maximize protection and minimize host injuryv
  • may play an inhibitory role in NK cell-mediated cytotoxicity against cancer cells, implying a possible mechanism of immune escape in human cancer
  • role for CD47-dependent phagocyte-mediated mechanisms for the control of hematopoietic cell numbers
  • homeostatic regulatory role of CD47–SIRPA interactions in the context of antibody-mediated destruction of tumor cells by myeloid cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • CD47/SIRPA signaling axis is particularly implicated in T-cell homeostasis
  • a component
  • constituent of the RH antigen multisubunit complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for PTPSN1 on macrophages surface
  • interaction with UBQLN1 and UBQLN2
  • levels of strongly influenced by protein 4.2
  • interact functionally with integrins and thrombspondin-1
  • associates with Fas upon its activation and augments Fas-mediated apoptosis
  • binds specifically to the inhibitory receptor signal-regulatory protein
  • CD47/SIRPA interactions are a major determinant of escape from phagocyte-mediated cell clearance
  • CD47–SIRPA interactions participate in a homeostatic mechanism that restricts antibody-mediated killing of tumor cells
  • ligand for SIRPA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    constitutively upregulated in myeloid leukemias
    tumoral     --over  
    in acute myeloid leukemia contributes to pathogenesis by inhibiting phagocytosis of these cells through the interaction of CD47 with SIRPA, and is associated with decreased overall survival
    tumoral     --over  
    in acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • important biomarker in breast cancer, and functions as a prognostic factor for disease-free survival
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    development of an anti-CD47 antibody therapy for treatment of acute lymphoblastic leukemia
    cancer  
    compelling target for therapeutic strategies that reduce its functional interaction with macrophage SIRPA and thus render these cancers susceptible to innate and adaptive immune system clearance
    neurologyacquired 
    may be a potential neurovascular target for stroke and brain injury
    cancer  
    blockade of its function leads to tumor cell phagocytosis and elimination. CD47 is therefore a validated target for cancer therapies
    ANIMAL & CELL MODELS
  • thymocyte numbers are reduced approximately twofold in CD47-/- mice