basic FUNCTION
| M1-specific deubiquitinase OTULIN is essential for preventing TNF-associated systemic inflammation |
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is critical for restraining life-threatening spontaneous inflammation and maintaining immune homeostasis |
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OTULIN and LUBAC function in a linear pathway, and highlight a previously unrecognized interaction between linear ubiquitination, regulators of cell death, and induction of type I interferon |
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non-catalytic function of OTULIN in the regulation of SNX27-retromer assembly and recycling to the cell surface |
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is critical for maintaining liver homoeostasis, suggesting that M1-linked polyubiquitin chains may play a role in regulation of MTOR signalling and metabolism in the liver |
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complex role of OTULIN in cellular homeostasis |
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is a deubiquitinase that specifically cleaves linear ubiquitin chains |
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importance of OTULIN for restraining skin inflammation and maintaining immune homeostasis |