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FLASH GENE
Symbol CHID1 contributors: mct - updated : 22-01-2009
HGNC name chitinase domain containing 1
HGNC id 28474
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Chid1 (89.3 pc)
homolog to murine Chid1 (87.9 pc)
Homologene
FAMILY
  • glycosyl hydrolase 18 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • acting as a chitinase
  • CHIA, CHIT1, CHI3L1, CHI3L2 and CHID1 exert important biological roles in the monocyte lineage and chronic inflammatory diseases
  • CHIA, CHI3L2 and CHID1 resulted unchanged during osteoclast differentiation, whereas CHIT1 and CHI3L1 increased significantly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    chitin catabolic process
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with STAB1 (Kzhyshkowska 2006)
  • cell & other
    REGULATION
    induced by interleukin-4 and dexamethasone in the macrophages (Kzhyshkowska 2006)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS