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FLASH GENE
Symbol DUSP26 contributors: shn/npt - updated : 15-09-2009
HGNC name dual specificity phosphatase 26 (putative)
HGNC id 28161
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a dual-specificity phosphatase domain that can dephosphorylate itself (Yu 2007)
    • HOMOLOGY
    interspecies ortholog to Dusp26, Mus musculus
    ortholog to Dusp26, Rattus norvegicus
    ortholog to DUSP26, Pan troglodytes
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
    • CATEGORY adhesion , tumor suppressor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • having a dual-specificity phosphatase domain that can dephosphorylate itself
  • may act as an oncogene in anaplastic thyroid cancer, and might be a useful diagnostic marker and therapeutic target of this disease
  • formed a physical complex with MAPK14, and promoted survival of anaplastic thyroid cancer cells by inhibiting MAPK14-mediated apoptosis (Yu 2007)
  • may be be involved in critical signaling events such as control of MAP kinases (Takagaki 2007)
  • Intracellular transport and cell –cell adhesion
  • dephosphorylates the Kap3 subunit of the KIF3 motor and
    • enhances N-cadherin-mediated cell–cell interactions
  • may have a tumor-suppressive function in brain tumors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    text catalyses dephosphorylation of protein phospho-
    Ser/Thr and phospho-Tyr residues
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with HSF4B places this transcription factor within a regulatory circuit in the MAP kinase signaling pathway
  • inactivates MAPK1 and MAPK3, inhibits MAP kinase p38 and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells
  • KIF3 and KAP3
    • cell & other
    REGULATION
    Other Dusp26 expression is downregulate in human brain tumors like glioblastoma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in anaplastic thyroid cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target useful diagnostic marker and therapeutic target of anaplastic thyroid cancer
    ANIMAL & CELL MODELS