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FLASH GENE
Symbol DTX3L contributors: mct/npt - updated : 11-07-2015
HGNC name deltex 3-like (Drosophila)
HGNC id 30323
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lacks the highly basic N-terminal motif and the central proline-rich motif present in other Deltex proteins, and instead contains other unique N-terminal domains
  • C-terminal region is highly homologous to that of DTX family members (Takeyama 2003), including a RING domain and a previously unidentified C-terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • Deltex family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • localizes to early endosomes upon CXCR4 activation
  • basic FUNCTION
  • function as E3 ligases based on its capacity for self-ubiquitination (Takeyama 2003)
  • regulates the subcellular localization of PARP9 by a dynamic shuttling mechanism, highlighting the functional requirement for coordinated DTX3L and PARP9 expression (Juszczynski 2006)
  • selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents (Yan 2009)
  • directly implicated in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response (Yan 2009)
  • selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents
  • directly implicated in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response
  • E3 ligase that regulates subcellular localization of its partner protein, PARP9, by a dynamic nucleocytoplasmic trafficking mechanism
  • selectively ubiquitylates histone H4 and indirectly promotes early TP53BP1 recruitment to DNA damage sites
  • DTX3L and PARP9 are bona fide members of a DNA damage response pathway and are directly associated with PARP1 activation, BRCA1 recruitment, and double-strand break repair
  • novel role for the really interesting new gene-domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes
  • DTX3L and PARP9 act together as repressors of the tumor suppressor IRF1 in prostate cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexes with PARP9 (Juszczynski 2006)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DTX1 (DTX1 associate via their unique N termini, resulting in enhanced self-ubiquitination) (Takeyama 2003)
  • interacts directly with and inhibits the activity of the E3 ubiquitin ligase atrophin-1 interacting protein 4
  • cell & other
    REGULATION
    Other regulated by a IFN-gamma-responsive bidirectional promoter (Juszczynski 2006)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS