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FLASH GENE
Symbol DPPA2 contributors: mct - updated : 30-01-2013
HGNC name developmental pluripotency associated 2
HGNC id 19197
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • DPPA2 and DPPA4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line
  • regulates chromatin structures, playing important roles in the maintenance of pluripotency and proliferation of embryonic stem cells
  • involved not only in the normal development of lung but also in the pathogenesis of non-small cell lung cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the regulatory region of NKX2-5 in ESCs, suggesting that it has important roles in lung development, where it is no longer expressed, by leaving epigenetic marks from earlier developmental stages (PMID;
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    promising target for antigen-specific immunotherapy in in non-small cell lung cancer
    ANIMAL & CELL MODELS