basic FUNCTION
| negatively regulates mitogen-activated protein kinase Erk downstream of protein-tyrosine kinases (PTKs)(Honma 2006) |
|
sequesters GRB2 from Shc and inhibits the Ras-Erk pathway downstream of PTKs (Honma 2006) |
|
plays a distinct and nonredundant role in the negative regulation of B-cell receptor (BCR) signaling |
|
adaptor protein that function in feedback loops to modulate tyrosine kinase signaling (Berger 2010) |
|
function in negative-feedback signaling loops that tightly modulate the duration and intensity of growth factor signaling (Berger 2010) |
|
is a negative regulator of TLR signaling by limiting LPS-induced ERK activation and cytokine responses in macrophages |
|
plays a role in TLR signaling during both na |
|
ve and endotoxin-induced tolerant conditions |
|
DOK1, DOK2, and DOK3 cooperatively play critical anti-inflammatory roles in lung homeostasis |
|
functions as a negative regulator and attenuates B-cell receptor-mediated calcium signaling |