Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DLGAP3 contributors: mct/npt - updated : 07-11-2009
HGNC name discs, large (Drosophila) homolog-associated protein 3
HGNC id 30368
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PDZ (DHR) domains
  • a SH3 domain
  • a guanylate kinase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • SAPAP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • anchoring protein for PTK2 and ASAP1 in post-synaptic densities and may contribute to the synaptic function of these tyrosine kinases (Bongiorno-Borbone 2005)
  • may have a potential activity to maintain the structure of postsynaptic density by concentrating its components to the membrane area (Takeuchi 1997)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PTK2 (residues 676-840) and ASAP1 (Bongiorno-Borbone 2005)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene a promising functional candidate gene for grooming disorders (GDs: pathologic nail biting, pathologic skin picking, and/or trichotillomania) (Bienvenu 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS